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It should be noted that KOR activity can modulate D2 autoreceptor-dependent decrease in dopamine release by signaling interaction Jackisch et al. A PET study of D 1 -like dopamine receptor ligand binding during altered endogenous dopamine levels in the primate brain. PET imaging studies also show that cocaine abuse is associated with both decreased [18F]DOPA uptake and striatal vesicular monoamine transporter 2 binding, which provide measures of pre-synaptic dopamine stores Wu et al. A review of the properties of spiradoline: Major coexpression of k-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. Chronic cocaine exposure induces CREB phosphorylation and changes in gene expression, which increase expression of prodynorphin mRNA in the nucleus accumbens in addition to other factors.
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